V Veena
REVA University, India
Title: Approaches in identification of suitable natural anticancer and anti-inflammatory molecules
Biography
Biography: V Veena
Abstract
Statement of the Problem: Several herbal and ayurvedic preparations are currently used to treat the cancer patients. Although, several herbs used in such treatment contains pharmacologically important molecules but they are yet to be identified and their mode of action is not studied in detail. Cancer is defined as a wound that never heals due to its complicated cellular organizations. Thus, the main objective of present investigation was to identify the herbal leads that target the inflammatory tumor environment through modern approaches.
The purpose of this study: India is the major country that is rich in the biodiverse compounds to treat disorders through herbal and ayurvedic approaches. Several natural lead molecules are being reported and continuously being investigated globally. The good examples are being curcurmin and taxol derivatives of natural origin that is effective against cancer and inflammatory disorders. Identification of small molecule drugs from herbs by increasing the selectivity towards tumor is the prime importance of the study. In this context, we have investigated several diverse herbal lead molecules that aimed to increase the selectivity and inflammatory aspects of heterogenic cancer components.
Methodology and Theoretical Orientation: The major photochemical components of herbs used in treatment of various disorders was screened to identify an active components based on preliminary studies. Further, through virtual screening, the compounds were identified against cancer specific targets by computational approaches. The results were validation by in vitro interaction studies and cell-based studies.
Findings: The lead molecules were obtained that can be used for in vivo studies for development of anticancer drugs. The findings also enriched the knowledge regarding mechanistic approach of ayurvedic drugs being used.
Conclusion and Significance: The active herbal constituents that target the multiple pathways which are deregulated in cancer was very useful to for identification of some pharmacologically important lead backbone and other vital components present in the herbs increased the selectively towards cancer could be identified. This study also enriched the knowledge regarding the mechanism of action of some Indian ayurvedic herbal preparations.