Muhammad Riaz
University of Sargodha, Pakistan
Title: Biological profiling and hepatorehabilitative potential of Mucuna pruriens in male albino rats
Biography
Biography: Muhammad Riaz
Abstract
The present research was conducted to study the biological profile and hepatorehabilitative potential of Mucuna pruriens (MP) seeds using male albino rats as animal model. For the study, methanolic extract of Mucuna pruriens seeds was prepared and antioxidant potential was determined. The seeds extract was screened for antimicrobial activity using well diffusion method. Results showed significant antioxidant potential and antimicrobial activity of extract. For hepatorehabilitative potential, the animals were divided into six groups intoxicated with Carbon Tetrachloride (CCl4) except the normal controls. The test group animals were treated with different doses of methanolic seeds extract. Significant (p<0.05) improvement in liver enzymes like ALT and AST activity was observed in dose dependent manner of seeds extract, while no significant improvement in ALP activity was observed as compared to control group animals. Significant (p<0.05) variation in serum total protein, albumin and globulin concentration was observed. Histopathology of liver tissue was also performed. Serious damage in liver cells (hepatocytes) structures in the CCl4 intoxicated group of animals was observed, while an improvement in the histoarchitecture of liver was observed in the positive control group animals treated with Silymarin and in the extract treated group animals. The study concluded that the Mucuna seeds possess antioxidant and antimicrobial activity with therapeutic potential and may be used for the preparation of hepatoprotective medicines